Clinical Research Services & Facilities
The Clinical Research Center (CRC) provides the UIC research community with a core of clinical research professionals. These individuals possess specialized training to provide a full array of clinical research services including, but not limited to: initial planning and logistics for a protocol, source document creation, data collection, performing testing or procedures required within a protocol, guidance regarding protection of research subjects, orientation of other professionals to clinical research facilitation, and education of subjects regarding clinical research.
The CRC nursing staff is comprised of registered nurses and advanced practice nurses with expert clinical knowledge and skills in vast areas of clinical practice. CRC clinical research coordinators also provide hands on clinical and laboratory support.
Integrative Physiology Lab
Clinical Research Center Facilities
Procedures performed by the CRC clinical staff include, but are not limited to:
- Measurement of vital signs
- Orthostatic blood pressures
- IV catheter insertion
- Investigational drug infusions
- Medication compliance assessment
- Timed pharmacokinetic studies
- Collection of urine/other biological fluids over specified time periods
- Subcutaneous fat biopsy (by APN)
- Oral Glucose Tolerance Tests
- Intravenous Glucose Tolerance Tests
- Fast-Sampling IV Glucose Tolerance Tests
- Euglycemic Clamps
- Insulin Clamps
- Administration of questionnaires/surveys
- Bioimpedance analysis
- Allergy skin testing
People who use clinical services also find the following links to be helpful:
The Clinical Research Center's resources include a specimen processing laboratory and a radioisotope laboratory.
The CRC Laboratory offers the following services:
- Processing of research specimens including blood, urine, stool, sputum, and saliva
- Point of Care Testing including blood glucose, hemoglobin, urine pregnancy, urine drug screen, urine dipstick
- Specimen shipping in accordance with IATA regulations
- Radioisotope laboratory facility available for radioisotope studies
- Temporary sample storage including refrigeration and -80 C
CRC personnel can work with various outside labs to help investigators obtain the clinical analysis needed on research specimens. Each investigator creates an independent account and will receive custom requisitions with the lab of their choice. Laboratories commonly used by CRC investigators include the UIC Lab, Quest Diagnostics, and Alverno Lab.
People who use laboratory services also find the following links to be helpful:
The Investigational Drug Service at UI Health assures appropriate storage, handling, drug accountability, information access and compliance with hospital policy and FDA, Joint Commission, state and federal standards. It is required that an investigational pharmacist dispenses all pharmacy-related substances. Investigational drugs and study-related information are accessible around the clock and throughout the year. When supplied with an order from a study physician, the Investigational Drug Service can dispense the appropriate study drug to the CRC or the patient. The Investigational Drug Service can also receive and document receipt of drug shipments. Arrangements can be made for study drugs to be received and dispensed after hours and on weekends.
The Investigational Pharmacist provides the following services:
- Proper drug storage (i.e., temperature, light, moisture, security, etc)
- Precise drug preparation according to the approved study protocol
- Proper dispensing of protocol-specific drugs
- Ensure randomization and blinding procedures are followed
- Maintain accurate records & inventory levels
Integrative Physiology Laboratory (IPL)
The CRC has a partnership wtih the College of Applied Health Science's Integrative Physiology Laboratory (IPL). The IPL concentrates on health-related research across several disciplines using translational approaches that are both cellular and whole-body in scope. The current faculty's research integrates aspects of cardiovascular function, metabolism, inflammation, hydration and nutrition status, and exercise/physical activity. They evaluate healthy individuals as well as at-risk populations or those who suffer from chronic diseases including hypertension, type 2 diabetes, kidney disease, and obesity. The IPL utilizes state-of-the-art applied and basic techniques to accomplish its research goals.
IPL Services Include:
- Resting metabolic rate (RMR)
- Dual-energy X-ray absorptiometry (DEXA)
- Maximal oxygen consumption (VO2 max)
- Carotid intima thickness (IMT)
- Pulse wave analysis/velocity
- Flow-mediated dilation (FMD), a non-invasive measure of vascular endothelial function
Clinical Research Center Facilities
The Clinical Research Center is located in the Neuropsychiatric Institute (NPI), 912 South Wood Street, 2nd floor, Room 200S. There is also a map and directions for handicap accessible entrances.
The facility includes:
- Outpatient area, including examination and procedure rooms
- Specimen processing laboratory
- Physiology laboratory
- Off campus assistance with clinical research procedures may be available; please contact the CRC for more details.